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1

The biology that underpins the therapeutic potential of cannabis-based medicines for the control of spasticity in multiple sclerosis

David Baker, Gareth Pryce, Samuel J. Jackson, Chris Bolton, Gavin Giovannoni

Journal:

Multiple Sclerosis and Related Disorders

Year:

2012

Language:

english

File:

PDF, 910 KB

english, 2012

2

The occurrence of defined idiotypes on autoantibodies to mouse thyroglobulin

David Male, Gareth Pryce, Ruby Quartey-Papafio, Ivan Roitt

Journal:

European Journal of Immunology

Year:

1983

Language:

english

File:

PDF, 668 KB

english, 1983

3

The therapeutic potential of cannabis

David Baker, Gareth Pryce, Gavin Giovannoni, Alan J Thompson

Journal:

The Lancet Neurology

Year:

2003

Language:

english

File:

PDF, 573 KB

english, 2003

4

TheIFITM5mutation c.-14C > T results in an elongated transcript expressed in human bone; and causes varying phenotypic severity of osteogenesis imperfecta type V

Lazarus, Syndia, McInerney-Leo, Aideen M, McKenzie, Fiona A, Baynam, Gareth, Broley, Stephanie, Cavan, Barbra V, Munns, Craig F, Pruijs, Johannes Egbertus, Sillence, David, Terhal, Paulien A, Pryce, K

Journal:

BMC Musculoskeletal Disorders

Year:

2014

Language:

english

File:

PDF, 193 KB

english, 2014

5

Memory B Cells are Major Targets for Effective Immunotherapy in Relapsing Multiple Sclerosis

Baker, David, Marta, Monica, Pryce, Gareth, Giovannoni, Gavin, Schmierer, Klaus

Journal:

Year:

2017

Language:

english

File:

PDF, 2.20 MB

english, 2017

6

Oligoclonal bands in multiple sclerosis; Functional significance and therapeutic implications. Does the specificity matter?

Pryce, Gareth, Baker, David

Journal:

Multiple Sclerosis and Related Disorders

Year:

2018

Language:

english

File:

PDF, 1004 KB

english, 2018

7

Synergy between interferons and monokines in MHC induction on brain endothelium

David Male, Gareth Pryce

Journal:

Immunology Letters

Year:

1988

Language:

english

File:

PDF, 351 KB

english, 1988

8

10.1038/35003583

Baker, David, Pryce, Gareth, Croxford, J. Ludovic, Brown, Peter, Pertwee, Roger G., Huffman, John W., Layward, Lorna

Journal:

Year:

2000

Language:

english

File:

PDF, 370 KB

english, 2000

9

Direct suppression of CNS autoimmune inflammation via the cannabinoid receptor CB1 on neurons and CB2 on autoreactive T cells

Maresz, Katarzyna, Pryce, Gareth, Ponomarev, Eugene D, Marsicano, Giovanni, Croxford, J Ludovic, Shriver, Leah P, Ledent, Catherine, Cheng, Xiaodong, Carrier, Erica J, Mann, Monica K

Journal:

Nature Medicine

Year:

2007

Language:

english

File:

PDF, 255 KB

english, 2007

10

New potent and selective inhibitors of anandamide reuptake with antispastic activity in a mouse model of multiple sclerosis

Alessia Ligresti, Maria Grazia Cascio, Gareth Pryce, Sanjitha Kulasegram, Irina Beletskaya, Luciano De Petrocellis, Bijali Saha, Anu Mahadevan, Cristina Visintin, Jenny L Wiley, David Baker, Billy R M

Journal:

British Journal of Pharmacology

Year:

2006

Language:

english

File:

PDF, 187 KB

english, 2006

11

Lymphocyte migration into brain modelled in vitro: Control by lymphocyte activation, cytokines, and antigen

David Male, Gareth Pryce, Christopher Hughes, Peter Lantos

Journal:

Cellular Immunology

Year:

1990

Language:

english

File:

PDF, 2.04 MB

english, 1990

12

Changes in CB1 receptors in motor-related brain structures of chronic relapsing experimental allergic encephalomyelitis mice

Ana Cabranes, Gareth Pryce, David Baker, Javier Fernández-Ruiz

Journal:

Year:

2006

Language:

english

File:

PDF, 221 KB

english, 2006

13

In vivo pharmacological actions of two novel inhibitors of anandamide cellular uptake

Eva de Lago, Alessia Ligresti, Giorgio Ortar, Enrico Morera, Ana Cabranes, Gareth Pryce, Maurizio Bifulco, David Baker, Javier Fernandez-Ruiz, Vincenzo Di Marzo

Journal:

European Journal of Pharmacology

Year:

2004

Language:

english

File:

PDF, 211 KB

english, 2004

14

Autoimmune tolerance eliminates relapses but fails to halt progression in a model of multiple sclerosis

Gareth Pryce, Janet K. O'Neill, J. Ludovic Croxford, Sandra Amor, Deborah J. Hankey, Emma East, Gavin Giovannoni, David Baker

Journal:

Journal of Neuroimmunology

Year:

2005

Language:

english

File:

PDF, 348 KB

english, 2005

15

Encephalitogenic and tolerogenic potential of altered peptide ligands of MOG and PLP in Biozzi ABH mice

Nicole Heijmans, Paul A. Smith, Margaret M. Morris-Downes, Gareth Pryce, David Baker, Anna V.J. Donaldson, Bert 't Hart, Sandra Amor

Journal:

Journal of Neuroimmunology

Year:

2005

Language:

english

File:

PDF, 235 KB

english, 2005

16

Epitope spread is not critical for the relapse and progression of MOG 8-21 induced EAE in Biozzi ABH mice

Paul A. Smith, Margaret Morris-Downes, Nicole Heijmans, Gareth Pryce, Elizabeth Arter, Janet K. O'Neill, Bert 't Hart, David Baker, Sandra Amor

Journal:

Journal of Neuroimmunology

Year:

2005

Language:

english

File:

PDF, 207 KB

english, 2005

17

Cannabinoid-mediated neuroprotection, not immunosuppression, may be more relevant to multiple sclerosis

J. Ludovic Croxford, Gareth Pryce, Samuel J. Jackson, Catherine Ledent, Gavin Giovannoni, Roger G. Pertwee, Takashi Yamamura, David Baker

Journal:

Journal of Neuroimmunology

Year:

2008

Language:

english

File:

PDF, 1.22 MB

english, 2008

18

An experimental model of secondary progressive multiple sclerosis that shows regional variation in gliosis, remyelination, axonal and neuronal loss

David W. Hampton, Jane Anderson, Gareth Pryce, Karen-Amanda Irvine, Gavin Giovannoni, James W. Fawcett, Alastair Compston, Robin J.M. Franklin, David Baker, Siddharthan Chandran

Journal:

Journal of Neuroimmunology

Year:

2008

Language:

english

File:

PDF, 4.09 MB

english, 2008

19

Practical guide to the induction of relapsing progressive experimental autoimmune encephalomyelitis in the Biozzi ABH mouse

Sarah Al-Izki, Gareth Pryce, Janet K. O'Neill, Colin Butter, Gavin Giovannoni, Sandra Amor, David Baker

Journal:

Multiple Sclerosis and Related Disorders

Year:

2012

Language:

english

File:

PDF, 332 KB

english, 2012

20

Arvanil-induced inhibition of spasticity and persistent pain: evidence for therapeutic sites of action different from the vanilloid VR1 receptor and cannabinoid CB1/CB2 receptors

Jason W. Brooks, Gareth Pryce, Tiziana Bisogno, Siân I. Jaggar, Deborah J.R. Hankey, Peter Brown, Daniel Bridges, Catherine Ledent, Maurizio Bifulco, Andrew S.C. Rice, Vincenzo Di Marzo, David Baker

Journal:

European Journal of Pharmacology

Year:

2002

Language:

english

File:

PDF, 272 KB

english, 2002

21

Emerging properties of cannabinoid medicines in management of multiple sclerosis

Gareth Pryce, David Baker

Journal:

Trends in Neurosciences

Year:

2005

Language:

english

File:

PDF, 112 KB

english, 2005

22

In silico patent searching reveals a new cannabinoid receptor

David Baker, Gareth Pryce, Wayne L. Davies, C. Robin Hiley

Journal:

Trends in Pharmacological Sciences

Year:

2006

Language:

english

File:

PDF, 103 KB

english, 2006

23

A Role for the Plasminogen Activator System in Inflammation and Neurodegeneration in the Central Nervous System during Experimental Allergic Encephalomyelitis

Emma East, David Baker, Gareth Pryce, H. Roger Lijnen, M. Louise Cuzner, Djordje Gverić

Journal:

The American Journal of Pathology

Year:

2005

Language:

english

File:

PDF, 905 KB

english, 2005

24

A Role for Caspase-1 and -3 in the Pathology of Experimental Allergic Encephalomyelitis: Inflammation Versus Degeneration

Zubair Ahmed, Anne I. Doward, Gareth Pryce, Deanna L. Taylor, Jennifer M. Pocock, John P. Leonard, David Baker, M. Louise Cuzner

Journal:

The American Journal of Pathology

Year:

2002

Language:

english

File:

PDF, 1.98 MB

english, 2002

25

Myelin/Axonal Pathology in Interleukin-12 Induced Serial Relapses of Experimental Allergic Encephalomyelitis in the Lewis Rat

Zubair Ahmed, Djordje Gveric, Gareth Pryce, David Baker, John P. Leonard, M. Louise Cuzner

Journal:

The American Journal of Pathology

Year:

2001

Language:

english

File:

PDF, 1.79 MB

english, 2001

26

Factors controlling T-cell migration across rat cerebral endothelium in vitro

Gareth Pryce, David Male, Iain Campbell, John Greenwood

Journal:

Journal of Neuroimmunology

Year:

1997

Language:

english

File:

PDF, 481 KB

english, 1997

27

Mifepristone or inhibition of 11β-hydroxylase activity potentiates the sedating effects of the cannabinoid receptor-1 agonist Δ(9)-tetrahydrocannabinol in mice

Gareth Pryce, Gavin Giovannoni, David Baker

Journal:

Neuroscience Letters

Year:

2003

Language:

english

File:

PDF, 84 KB

english, 2003

28

UCM707, an inhibitor of the anandamide uptake, behaves as a symptom control agent in models of Huntington's disease and multiple sclerosis, but fails to delay/arrest the progression of different motor-related disorders

Eva de Lago, Javier Fernández-Ruiz, Silvia Ortega-Gutiérrez, Ana Cabranes, Gareth Pryce, David Baker, Mariluz López-Rodríguez, José Antonio Ramos

Journal:

European Neuropsychopharmacology

Year:

2006

Language:

english

File:

PDF, 203 KB

english, 2006

29

An assay for the analysis of lymphocyte migration across cerebral endothelium in vitro

Gareth Pryce, Washington Santos, David Male

Journal:

Journal of Immunological Methods

Year:

1994

Language:

english

File:

PDF, 1.33 MB

english, 1994

30

Structural features of the autoantigens involved in thyroid autoimmune disease: The thyroid microsomal/microvillar antigen

J.Paul Banga, Gareth Pryce, Linda Hammond, Ivan M. Roitt

Journal:

Molecular Immunology

Year:

1985

Language:

english

File:

PDF, 2.96 MB

english, 1985

31

Molecular analysis of induced idiotypes associated with autoanti-thyroglobulin

David Male, Gareth Pryce, Ivan Roitt

Journal:

Molecular Immunology

Year:

1985

Language:

english

File:

PDF, 1.50 MB

english, 1985

32

Induction of Ia molecules on brain endothelium is related to susceptibility to experimental allergic encephalomyelitis

David Male, Gareth Pryce

Journal:

Journal of Neuroimmunology

Year:

1989

Language:

english

File:

PDF, 242 KB

english, 1989

33

Comparison of the immunological properties of rat cerebral and aortic endothelium

David Male, Gareth Pryce, Jameel Rahman

Journal:

Journal of Neuroimmunology

Year:

1990

Language:

english

File:

PDF, 612 KB

english, 1990

34

Control of lymphocyte migration across cerebral endothelium

David Male, Gareth Pryce, Adam Linke, Jameel Rahman

Journal:

Journal of Neuroimmunology

Year:

1991

Language:

english

File:

PDF, 82 KB

english, 1991

35

Lymphocyte migration into the CNS modelled in vitro

David Male, Gareth Pryce, Adam Linke, Jameel Rahman

Journal:

Journal of Neuroimmunology

Year:

1992

Language:

english

File:

PDF, 335 KB

english, 1992

36

Transendothelial T-cell migration is dependent on antigen stimulation, IL-2, time and adhesion molecule expression

Gareth Pryce, John Greenwood, David Male

Journal:

Journal of Neuroimmunology

Year:

1994

Language:

english

File:

PDF, 140 KB

english, 1994

37

Cannabinoids and neuroprotection in CNS inflammatory disease

Samuel J. Jackson, Lara T. Diemel, Gareth Pryce, David Baker

Journal:

Journal of the Neurological Sciences

Year:

2005

Language:

english

File:

PDF, 101 KB

english, 2005

38

Neurodegeneration progresses despite complete elimination of clinical relapses in a mouse model of multiple sclerosis

Hampton, David W, Serio, Andrea, Pryce, Gareth, Al-Izki, Sarah, Franklin, Robin JM, Giovannoni, Gavin, Baker, David, Chandran, Siddharthan

Journal:

Acta Neuropathologica Communications

Year:

2013

Language:

english

File:

PDF, 2.53 MB

english, 2013

39

Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis

Puentes, Fabiola, van der Star, Baukje J, Victor, Marion, Kipp, Markus, Beyer, Cordian, Peferoen-Baert, Regina, Ummenthum, Kimberley, Pryce, Gareth, Gerritsen, Wouter, Huizinga, Ruth, Reijerkerk, Arie

Journal:

Journal of Neuroinflammation

Year:

2013

Language:

english

File:

PDF, 910 KB

english, 2013

40

Inhibition of relapsing experimental autoimmune encephalomyelitis in Biozzi ABH mice using a mouse CD52-specific monoclonal antibody

Von Kutzleben, Stephanie, Pryce, Gareth, Chretien, Nathalie, Turner, Michael, Siders, William, Baker, David

Journal:

Journal of Neuroimmunology

Year:

2014

Language:

english

File:

PDF, 51 KB

english, 2014

41

The therapeutic potential of cannabis in multiple sclerosis

Baker, David, Pryce, Gareth

Journal:

Expert Opinion on Investigational Drugs

Year:

2003

Language:

english

File:

PDF, 116 KB

english, 2003

42

The enantioselective synthesis of an important intermediate to the antiviral, (?)-carbovir

Handa, Sheetal, Earlam, George J., Geary, Phillip J., Hawes, John E., Phillips, Gareth T., Pryce, Robert J., Ryback, George, Shears, Jeremy H.

Journal:

Journal of the Chemical Society Perkin Transactions 1

Year:

1994

Language:

english

File:

PDF, 276 KB

english, 1994

43

A Rapid Assay for Immunoglobulin in Hybridoma Supernatants

Male, David, Pryce, Gareth

Journal:

Immunological Investigations

Year:

1983

Language:

english

File:

PDF, 305 KB

english, 1983

44

Brain endothelial miR-146a negatively modulates T-cell adhesion through repressing multiple targets to inhibit NF-κB activation

Wu, Dongsheng, Cerutti, Camilla, Lopez-Ramirez, Miguel A, Pryce, Gareth, King-Robson, Josh, Simpson, Julie E, van der Pol, Susanne MA, Hirst, Mark C, de Vries, Helga E, Sharrack, Basil, Baker, David,

Journal:

Journal of Cerebral Blood Flow and Metabolism

Year:

2015

Language:

english

File:

PDF, 2.83 MB

english, 2015

45

Neuroprotection in Experimental Autoimmune Encephalomyelitis and Progressive Multiple Sclerosis by Cannabis-Based Cannabinoids

Pryce, Gareth, Riddall, Dieter R., Selwood, David L., Giovannoni, Gavin, Baker, David

Journal:

Journal of Neuroimmune Pharmacology

Year:

2015

Language:

english

File:

PDF, 499 KB

english, 2015

46

Cannabinoids fail to show evidence of slowing down the progression of multiple sclerosis

Pryce, Gareth, Baker, David

Journal:

Evidence-Based Medicine

Year:

2015

Language:

english

File:

PDF, 89 KB

english, 2015

47

Neurofilament a biomarker of neurodegeneration in autoimmune encephalomyelitis

Gnanapavan, Sharmilee, Grant, Donna, Pryce, Gareth, Jackson, Sam, Baker, David, Giovannoni, Gavin

Journal:

Year:

2012

Language:

english

File:

PDF, 146 KB

english, 2012

48

Selective inhibition of the mitochondrial permeability transition pore protects against neuro-degeneration in experimental multiple sclerosis.

Warne, Justin, Pryce, Gareth, Hill, Julia, Shi, Xiao, Lennerås, Felicia, Puentes, Fabiola, Kip, Maarten, Hilditch, Laura, Walker, Paul, Simone, Michela I., Chan, A.W. Edith, Towers, Greg J., Coker, Al

Journal:

Journal of Biological Chemistry

Year:

2015

Language:

english

File:

PDF, 1.77 MB

english, 2015

49

The Endocannabinoid System and Multiple Sclerosis

Baker, David, Pryce, Gareth

Journal:

Current Pharmaceutical Design

Year:

2008

Language:

english

File:

PDF, 204 KB

english, 2008

50

Pentraxin-3 is upregulated in the central nervous system during MS and EAE, but does not modulate experimental neurological disease

Ummenthum, Kimberley, Peferoen, Laura A. N., Finardi, Annamaria, Baker, David, Pryce, Gareth, Mantovani, Alberto, Bsibsi, Malika, Bottazzi, Barbara, Peferoen-Baert, Regina, van der Valk, Paul, Garland

Journal:

European Journal of Immunology

Year:

2016

Language:

english

File:

PDF, 809 KB

english, 2016